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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

[di'sin]
网队重建的欲望已经超越了给波士顿另一个高顺位签的不情愿。大坑已经挖好,想要从坑里爬出来,你能做的只有:一步一步地,挑出合适的新秀,交易球员,以及签约。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Mr Cook has added three women to what was previously a white-male-dominated executive team and changed Apple’s board charter to commit to seeking out candidates from minorities when appointing directors.
不要为WTO哭泣

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

恭贺新禧,祝身体健康、事业发达。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Mr Lam predicts that any recovery in the market will rely on appetite from cash-rich companies from mainland China, with foreign investors restricting their investments to real estate investment trusts or stocks exposed to developers, rather than actual property.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

凯文·杜兰特
每一次我们詹姆斯已经达到了顶点,詹姆斯就会拿出更好的表现超过那个顶点。他那无所不包的各项技巧,是詹姆斯辛苦训练的证明。你可以嘲笑他所提发布的所有Instagram录像,但这些都是他仍然能够做到这一点的真正原因;詹姆斯从来不轻视他的每一场比赛,一次都没有。结果便是晚上一次又一次无可比拟的表演。
“这不是可持续的增长,因为它们并未被租出去,当地市场的喊价者们并不会购买。”
However the prolonged period of contraction fits with the overall pattern of the slowing Chinese economy.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

与此同时,大学毕业生选择继续深造的意向也降低了,这让今年选择就业的人数比例达到了75.6%,而去年这一数据为71.2%。
特斯拉(Tesla) Model 3s的产量会超过25万辆吗?
As the fashion world mourns Lagerfeld, his beloved cat Choupette is one of a number who could be set to inherit his £150million fortune.
vt. 领航,驾

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Mr Hoogewerf said that Mr Wang delisted his group’s property arm from the Hong Kong stock exchange this year in the hope of realising a richer valuation for it on the Shanghai or Shenzhen bourse.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

“写这本书的一大挑战是异性恋男人能改变一个女人的生活并使她死心塌地的看法。”

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

答:写轻小说的时候,我大部分时候都是独自创作。但是写动画的话,就有会导演,有工作人员,他们会对我的作品提出观点。关于分镜往往会有好几次修订。有趣的是那些回馈回来的东西。这是工作中非常有趣的一部分。
Video footage recorded by the RSPCA shows the house littered with mess, including animal faeces.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

The pair stand on opposite sides backstage and memorize the winners to avoid having to write them down and have revealed in the past how they carry out rigorous checks to ensure they have stuffed the envelopes correctly. It is believed Ruiz and Cullinan are ordered to destroy the duplicate cards as the presentation goes on, so by the time Best Picture is awarded, the only envelopes left are the two for Best Picture.
v. 燃烧,面红,爆发

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Only the US-based MIT Sloan School of Management, in fifth place, prevented French institutions from sweeping the top five positions.
Sina's Weibo service, for example, has long offered features that Twitter lacks, notably a commenting function that allows multiple users to add their own thoughts to a user's posts. Tencent's QQ instant messaging service, which has more than 700 million users, offers additional features such as skins to change the look of the client and serves as a portal for the company to advertise other products and services. Sina declined to comment.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

那么,于汽车业而言,2015年又意味着什么?以下是一些有根据的猜测。
失业率的大幅下降的实际效果将会有所体现
It came as no surprise that the likes of Emily Ratajkowski, Adriana Lima, Lily Donaldson and Petra Nemcova turned out to be the red carpet rulers on day one of the 70th Cannes Film Festival.
Premiered in August, the 48-episode TV series is a fictional story, with a plot centering on struggles and romance during the Qin Dynasty (221-206 BC).

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

15. “The End of the Tour” (James Ponsoldt)

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
From the themed collection: 土地市场调控成果须继续巩固
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

[h?b]
《发生什么了,西蒙妮小姐?》(What Happened, Miss Simone?),导演:利兹·加布斯(Liz Garbus)。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

质检总局副局长梅克保说道:“各级质量监督部门必须加强质量监督、继续打击违法行为,从而提高产品质量、保护消费者的权利。”

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 热点城市新房价格上月没涨
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Heavy air pollution from Beijing, which saw its worst bout of smog in recent history in January, to Shanghai, where pollution levels went off the charts in December, certainly don't do much to help attract tourists.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

reservation
He then proceeded to ram the violin through the canvas.
第10、11题,选0得4分,选1得3分,选2得2分,选3得1分,选4得0分。
今年1至10月份的民间固定资产投资同比增长2.9%,比1至9月份的增速快了0.4个百分点。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

We learned about the causes and consequences of rising obesity around the world.
担忧、紧张、抑郁和愤怒等负面情绪更常在D型人格的人身上体现。一件常常被他人忽视的小事就可能让D型人格的人烦恼,甚至会破坏他的心情。
就国内而言,日益活跃的中产阶层正形成压力,要求得到问责制度更健全的治理。愈演愈烈的不平等滋生了一种不公正感;两亿农民工仍然受到二等公民的待遇,腐败也有增无减。对付这些问题的任务十分紧迫,但中国的经济成就助长了一种无端的自信。于是,在阿拉伯之春的刺激下,中国的体制采取激进举措,压制可能引发政治敏感运动的任何社会不满。
I'm not worried about Philly, Phoenix, or Minnesota. They're young, they're rebuilding. If they make strides, great. If not, take another high pick. The Nets are the Nets and we should talk about them in a minute.
Comedy Series: “Veep” (HBO)

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

Bringing harmony to Apple’s internal fiefdoms has not been easy. There is still “huge tension” inside Apple, according to one person who has worked with the company for many years. “That tension is something he uses to run the company but it can be dangerous.”
Federal, state and local government job cutbacks are slowing. More than 250,000 workers at all levels of government lost jobs last year. This year, so far, about 20,000 have gained jobs. Worries about the nation's debt and deficits likely will keep a lid on government spending and investments, economists say, but any jumps in, say, infrastructure spending would create jobs. At the least, government will be less of a drag.[qh]

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Another slowdown in food prices pulled Chinese inflation lower in October, according to the National Bureau of Statistics.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
From the themed collection: 家居企业上市潮或破行业竞争格局
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

从eBay的Magento电子商务系统、IBM和NetSuite等知名企业到规模较小的Shopify和Volusion等,很多科技公司都希望从中分一杯羹。但相对冷门的Bigcommerce正在悄悄引发关注并窃取市场份额。它吸引了超过7,500万美元的风投资本,其中4,000万美元来自企业家史蒂夫o凯斯的Revolution Growth公司。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 全屋定制成为卫浴行业新模式
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

研究集团龙洲经讯(Gavekal Dragonomics)的陈龙表示,如今分析师们认为,中国银行业的盈利性增长机会差不多用完了。
But what will politicians actually do While President Trump is focused on bringing back traditional manufacturing jobs to America, different US states are experimenting with other policies to help low-paid precarious workers. These range from sharply higher minimum wages to new rules to stop employers changing staff schedules at the last minute.
6.Gal Gadot
A Saudi Woman Who Got Behind the Wheel and Never Looked Back

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Belgium, for example, has less than a tenth of the population of Russia, its rival in the group stage, but is regarded as a far greater threat. And then there is Uruguay, which despite fewer than 4 million citizens -- barely a sixth of the population of greater S?o Paulo -- is one of the teams Brazil would least like to meet on its way to the final. How is this so?
"Many companies operating with reduced staff levels are bringing in reinforcements to relieve their overworked teams," notes Max Messmer, Robert Half's chairman and CEO. "While some firms are backfilling positions out of necessity, businesses are also hiring to accommodate anticipated growth in 2011."
在根据真实罪案改编的电影《狐狸猎手》(Foxcatcher)中,以出演喜剧闻名的演员史蒂夫·卡瑞尔(Steve Carell)饰演大富翁约翰·E·杜邦(John E. du Pont)时隐藏在假面具后面。这个造型最突出的就是鸟嘴状鼻子。
Security questions risks

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

The Brexit trade uncertainty
根据北京市统计局发布的一份报告显示,2015年北京市社会消费品零售总额突破万亿元,达到了10338亿元,同比增长7.3%。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

intended
We will make big moves to improve the environment for foreign investors.
据中国的官方媒体报道,2017年中国电影票房收入增长了13.5%,而今年仅略有下降。
The remaining of the top 10 were the University of Luxembourg (second), Ecole Polytechnique Federale de Lausanne (fourth), University of Geneva (fifth), ETH Zurich - Swiss Federal Institute of Technology Zurich (seventh), University of St. Gallen (eighth), National University of Singapore (ninth) and Imperial College London (10th).
当你和他/她在一起的时候,你看不见周围的所有人,你的眼中只有他/她

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

I do not see much evidence that radical “managerless” models such as “Holacracy” will catch on. But more companies will realise that if they constantly test innovative ways forward — as start-ups do — they will be more flexible and decisive than old-style bureaucracies and meritocracies.
“Someone left for lunch and never came back.”
No students or teachers drank the poisoned water, the report said.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

荷兰首相马克?吕特(Mark Rutte)最近由于对安卡拉立场强硬而在民调中排名上升。吕特所属的自由民主人民党(VVD)在民调中略微领先自由党。周二,他将埃尔多安的言论称为“对历史令人恶心的歪曲”,还称“我们不会自甘堕落至这种水平。这完全不可接受”。
谎言3:是的,这挺有道理的。说谎原因:方案二会让我显得毫无头绪。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

时间:2009-11-19 编辑:vicki
Emerging market focused fund groups have endured a torrid year with sharply lower assets under management at Aberdeen and Ashmore. Emerging market exchange traded funds have also suffered heavy redemptions, with investors pulling $9.5bn from BlackRock’s iShares MSCI Emerging Markets and Vanguard’s FTSE Emerging Markets, according to ETF.com.
在气候学的史册里,2014年超过了2010年,成为最热的年份。有记录以来的10个最暖年份都是在1997年以后,反映了地球不断变暖的趋势,科学家说,这种变暖是人类活动的结果,并对人类文明和大自然构成了深远的长期危险。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

我们第一次看到安娜·莫拉莱斯(Anna Morales,杰西卡·查斯坦[Jessica Chastain]饰)的头发是在《至暴之年》(A Most Violent Year)的片头字幕里。她正对着镜子化妆。
The report provided in-depth observations on 28 Chinese business and administrative capitals - excluding Beijing and Shanghai - using several indicators.
Russian President Vladimir Putin says he wants to develop better ties with the United States no matter who wins next year's U.S. presidential election.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

从该剧2007年首播至今,我们似乎患上了哈德利·弗里曼(Hadley Freeman)在《卫报》(The Guardian)上所称的“广告狂人狂热症”(madmenalaria)。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

坚持依法全面履职。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
From the themed collection: 智能家居或成BAT下一个竞逐点
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

After a run with One Direction, Harry Styles could have gone anywhere he wanted.
Common and Day will perform "Stand Up For Something" from "Marshall" and Settle will perform "This is Me" from "The Greatest Showman."

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

Though many people associate Porsche with pure performance cars, in recent years the brand has expanded their lineup to include the Panamera, a luxury large car shown here, as well as the Cayenne and Macan SUVs. According to most reviewers, the Panamera not only lives up to the performance heritage of the Porsche’s brand, but also coddles occupants with an opulent interior and the connectivity features today’s luxury buyer demands.
库克公开性取向的举动,提供了一个罕有的机会,让人们得以一窥他保护严密的个人生活,但同时也让苹果品牌在一些不太宽容的地方面临风险。库克在阿拉巴马州长大的经历促使他作出此举,他曾说在阿拉巴马州看到的一些歧视现象“简直让我感到恶心”。
Three leading energy agencies recently said production from outside the Organization of the Petroleum Exporting Countries would increase this year, much of it from U.S. shale. Added to that is the possible return to market of millions of Middle East barrels as Iran, Iraq and Libya potentially ramp up production. All of that is set to press on prices.
如果说2017年是政策制定者们开始担心“无保障无产阶级”(precariat)人数增长的一年,那么2018年将是他们尝试为此做些什么的一年。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

The fundamentals of the Chinese economy remain sound, the capital adequacy ratio and provision coverage of commercial bans remain high, and we have many financial tools and instruments that can be used. We have the confidence, the ability, and the means to forestall systemic risks.
5.品牌推广:增长了16.4%

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 深度贫困地区可灵活使用宅基地
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

Subdivided flats smaller than 100 square feet (9 square meters) can rent for $385 in the Asian city.
Some 930,000 people sat the National Public Servant Exam in China on Nov. 29 last year, a 60,000 decrease year on year. But the 27,000 positions on offer was a new high.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

减薪前奥朗德的年收入为25.56万欧元(约合27万4522美元),仅次于美国总统奥巴马。但现在他的年收入仅为19.87万美元。众所周知,他的御用理发师年收入高达13.2万美元。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

Over the past 20 years, at least 133,000 units in the city have gone market rate because of this rule, according to the Rent Guidelines Board. If the trend continues, rent stabilization could be further weakened, undermining Mayor de Blasio’s efforts to preserve affordable housing, say supporters of the policy.
10. Am I worrying about the future? Worrying about something that hasn’t even happened yet causes stress and anxiety. Focus on the moment in front of you and realize that it is all that exists.
CPI increase kept around 3 percent.
大多数观察家认为去年五月首飞的单过道C919就是图中这架飞机。尽管这是一项突破性进展,但它并不能完全代表中国航空工业的发展。其他两个例子更有说服力。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

8 April
要实现有效的电子邮件营销,可不只是偶尔发一封电子文宣邮件那么简单。要想构建一套有效的电子邮件营销战略,你需要一个功能齐全的工具。MailChimp似乎是市面上最佳的此类系统,它提供了各种典雅直观的电邮广告模板、先进的分段功能和营销自动化功能。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

The fall in profits in December highlights the challenges facing an industrial sector racked by overcapacity and falling prices, adding to pressure on authorities to loosen monetary policy and boost infrastructure spending to cushion the slowdown.
n. 光泽,上光剂,优雅,精良
China Everbright, the financial conglomerate that bought the Dah Sing Financial Centre for HK$10bn ($1.29bn), is just one of a number of mainland Chinese companies to have splashed out on headquarters in the city over the past year.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

支持两国之间双向旅游的最新倡议包括以下几点:审查10年旅游签证;安排开放的航空市场服务以消除双方航空公司的所有容量限制;Qantas航空公司于1月推出北京到悉尼的新服务等。
The Pelicans have struggle to attract and keep free agents, they must retain Jrue Holiday this summer, Cousins is from nearby Alabama and enjoys a close friendship with Anthony Davis, and years of disappointing and injury-plagued seasons put the franchise in a position where it seemed to be teetering on perennial also-ran status.
《伯德小姐》

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

3. Piggyback Rider
伞上的链子可以系在狗狗的项圈或背带上。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

"It's a great conservation success story."
Some 695 million netizens used mobile phones to access the Internet in 2016, with a growth rate exceeding 10 percent for the third straight year, the report said. Smartphone-based Internet use accounted for 95.1 percent of all Internet users, up from 90.1 percent in 2015.
protein

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

5. Life is like a coffee table: it’s got tea sets and dinnerware all over it. (beiju, 杯具, is a homophone for tragedy, 悲剧, and dinnerware, canju, 餐具, a homophone for disaster, 惨剧).
如何找到IP地址

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

织密扎牢民生保障网。
以下是人们经常用来描述自己的一些句子。
5. Bank of America Corp.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 卫生洁具选购三步曲
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

喜剧类最佳男演员:杰佛里?塔博(Jeffrey Tambor),《透明家庭》(Transparent)

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

['depjuti]
Among the amenities spread through its three terminals are two 24-hour movie theaters screening the latest blockbusters for free, a rooftop swimming pool and a butterfly garden.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

上榜理由:食物、文化和恐怖故事
"The guy must have weighted the pros and cons of the situation: he had a great chance to survive a stranded elevator, but would have been doomed if he left homework undone," joked @Zealshifang.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 定制家具或将成为下一个竞争点
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

联邦控制委员会要求修订的财政计划必须在1月底前批准,举出加西亚去年提交的部份是不现实的,并过度依赖联邦资金。加西亚拒绝提交一项修订计划,包括紧缩措施。罗塞略已经表示,他将要求延长还款期限与在2月到期的延缓偿付,目前保护波多黎各避免被愤怒的债权人诉讼。
About 980 million yuan of illicit assets were recovered, according to the Communist Party of China Central Commission for Discipline Inspection.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

popul人民+ation→人口
网队我认为倒是可以轻松舒适地摆着烂,除非是想给那些没有融入球队文化,并且明年不会在队中地球员增加身价。对,我说的就是布鲁克-洛佩兹。他存在的交易价值很诡异,但是我们假设它存在的话,我们就该充分利用他身上的价值。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

本文作者为卡内基国际和平基金会(Carnegie Endowment)高级研究员、世界银行(World Bank)中国业务局前局长,译者/何黎

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

愿一切最美好的祝福都能用这张贺卡表达,真诚地祝你幸福、快乐、成功!
我发现自己很难开启一段对话
In addition to the overall ranking, US News also offers region-, country- and subject-specific rankings, to allow for more tailored searching.
在2010年世界杯中,智利当属最振奋人心的一支队伍,并在最近的温布利比赛中让英格兰队在赛场上四处兜转,不过,如果哥伦比亚队能够融合射手拉达梅尔·法尔考(Radamel Falcao),那么这支队可能会让一两支队伍神伤了。因此,在所有的南美洲球队中,似乎只有厄瓜多尔难以走出小组赛,而其余的所有国家都有能力奋战到后面的阶段。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

该银行表示,由于利率只会缓慢上行,大宗商品可能会吸引那些寻找更高收益率的对冲基金和其他投机客。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

3.贾君鹏,你妈妈喊你回家吃饭。
荷兰合作银行是面向全球农户和农业企业的领先融资机构。
Succeeding as an entrepreneur takes hard work and persistence because, unfortunately, there is no business-startup fairy who magically bestows success on small businesses and their owners.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

The very best bosses I’ve seen are passionate about their work; they live and breathe their jobs and strive to do the best work possible. Yet at the same time, they have lives outside of work. They understand the need to balance family and work or play and work. And they set a good example of how to do that for their employees。
自2007年4月以来,全球最具价值品牌100强的品牌价值增长106%。同期标准普尔500指数(S&P 500)和MSCI明晟全球指数(MSCI world index)分别上涨61%和21%。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

The computer is a very powerful machine built with ARM processors, the kind low-power processors that run smartphones and tablets. These servers allow more computing power o be packed into a smaller space. And that has big implications for building green-but-powerful data centers."I think of myself as an entrepreneur besides just being an electrical engineer. I believe what I'm doing can have a major effective on the world," Sohmers said.He dropped out of high school to join Peter Thiel's controversial startup accelerator, the 20 Under 20 Thiel Fellowship. Thiel, the former PayPal CEO and famous Silicon Valley venture capitalist known for his early investment in Facebook, is a libertarian who has often spoken out about the absurd cost of college these days.So in 2011, he started a program that encourages kids to start companies instead of going to college. It gives them $100,000 in seed money and access to some of the Valley's greatest technologists as mentors.Sohmers is an electrical engineering prodigy who at age 13 started working at the research lab at MIT. That's where he met his co-founder and CTO, Keville, he said.
Mr Trump is almost a textbook demagogue.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

海莉·威廉姆斯依然是颇有影响力的重要存在,一位不论是低声哼唱还是大声呐喊都能令人信服的歌手。她直言不讳的勇气几乎使你忘记《欢笑过后》记录的是她对这个世界的厌倦。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

根据最新相关报告表示,亚马逊凭借在数据中心、设备、电子方法和系统等方面的创新而上榜。
“Why do we keep getting so many record-warm years?” Dr. Schmidt asked in an interview. “It’s because the planet is warming. The basic issue is the long-term trend, and it is not going away.”
To start with, a year before the first iPhone was released, LG had introduced a full touchscreen phone. Even that was not the first, though. The world's first touchscreen phone was IBM's Simon, which was released in 1992. And touchscreen technology even predates the Simon. The first touchscreen device was a tablet made by E.A. Johnson in 1965 that was used by air traffic controllers until 1995. Bent Stumpe and Frank Beck made the first capacitive touchscreen in the early '70s. Unlike Johnson's tablet, it could not be pressed with the fingers. Instead, it required a stylus. In 1971, Samuel Hurst developed the first resistive touchscreen, which he called the "elograph." It responded to the fingers as well as a stylus. In 1985, HP invented the world's first touchscreen computer, called the HP-150. In 1993, Apple also released its first touchscreen device—the Newton Personal Digital Assistant. The product was a flop, recording low sales.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

The list presents an annual snapshot of the ever-changing global business landscape. The U.S. holds onto its crown as the country with the most Global 2000 companies: 564. Japan trails the U.S. with 225 companies in aggregate, despite losing the most members (26) this year.
[kɑ:st]
Be Professional
在排行榜19年历史上,这是首次出现由两所院校包揽这两项排名头两名的情况。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

里尔宁援引了荷兰经济政策分析局(CPB Netherlands Bureau for Economic Policy Analysis)的最新数据,数据显示,9月至10月经季节性调整的全球贸易量下降了1.1%,他表示,去年将被证明是世界贸易自2009年以来表现最糟糕的一年。
预计新一代iPhone中,将至少有一款采用人脸识别技术,这种图像捕捉技术能够感知深度,并追踪人脸及表情。随着苹果与Facebook和Snapchat等公司争夺用户的关注度,新一代iPhone将增加一系列包括猴子和机器人的新表情符号,其动画表情能够反映iPhone用户的脸。

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Good luck, good health, hood cheer. I wish you a happy New Year.
飓风厄玛在美国和全球的搜索排名图表中都位居前列,马特·劳拉成为在美国和世界搜索中人物搜索的第一名。这里是美国和全球排名前十的顺序表:
俄罗斯的SKN公司将老旧俄国弹药制作成钻石。这就是回收利用!

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

此次涵盖95个项目(去年为90个)的排行榜中,来自7个国家的9所院校为首次进入榜单。排名第41位的法兰克福金融管理学院(Frankfurt School of Finance & Management)是今年排名最高的新入榜者。这家德国学院拥有性别比例最平衡的项目之一,女性占学员总数的49%。
近些年来,细菌感染卷土重来,受害者达到了自1960s以来从所未见的最高值,初步确诊者的人数从429跃升至1300多人,从2011年到2017年期间的感染人数翻了两倍不止。

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